abstract：:The influence of human stromal fibroblasts cultured from normal, non-malignant and malignant breast tissues on in vivo growth of human breast tumour cells was studied. Earlier appearance and increased incidence were observed when low cell inocula of breast MDA-MB 231 tumour cells were coinjected with fibroblasts from ...

journal_title：Anticancer research

authors： Brouty-Boye D,Raux H

更新日期：1993-07-01 00:00:00

abstract：:The expression of the proto-oncogene c-myc has been strongly implicated in the regulation of apoptosis. Since we have previously shown apoptosis to occur in HL-60 leukemic cells exposed to the prodrug Mafosfamide (ASTA Z 7557), the present study was undertaken to examine the levels of c-myc mRNA transcripts in such ce...

journal_title：Anticancer research

authors： Davidoff AN,Mendelow BV

更新日期：1993-07-01 00:00:00

abstract：:The phospholipases are an important class of enzymes for growth factor and oncogene intracellular signalling. The anti-tumor drug suramin was found to inhibit phosphatidylcholine hydrolysis and trans-phosphatidylation by solubilized rat brain phospholipase D (PLD) with an IC50 of 15 microM. An azo analogue of suramin,...

journal_title：Anticancer research

authors： Gratas C,Powis G

更新日期：1993-07-01 00:00:00

abstract：:The generation of MHC-unrestricted cytotoxicity of highly enriched human CD3+ T cells (95-99%) by treatment with IL-2 and/or anti-CD3 antibodies was studied. T cells obtained by positive immunomagnetic sorting (anti-CD3) developed comparable specific cytotoxicities against K562 and Daudi cells when cultured with IL-2 ...

journal_title：Anticancer research

authors： Zollner TM,Zhu HG,Anderer FA

更新日期：1993-07-01 00:00:00

abstract：:A new cell line, designated CC2/CUHK2, was established from a squamous carcinoma of the uterine cervix from a Chinese patient. The cell line grew well without interruption for over 12 months and over 90 passages. The doubling time of CC2/CUHK2 was 72 hours at passage 57. When seeded at a density of 1.5 x 10(3) cells p...

journal_title：Anticancer research

authors： Ho TH,Chew EC,Tam JS,Hou HJ,Yam HF,Chew-Cheng SB,Wong FW

更新日期：1993-07-01 00:00:00

abstract：:Hexamethylmelamine (HMM) has previously been shown to be active against ovarian, breast and small cell lung cancer. However HMM dose not have aromatase-inhibitory activity. A newly developed HMM derivative, 2-N,N-dimethylamino-4, 6-bis (1-H-imidazol-1-yl)-1,3,5-triazine (SAE9), was found to have direct antitumor activ...

journal_title：Anticancer research

authors： Tanino H,Kubota T,Yamada Y,Koh JI,Takeuchi T,Kase S,Furukawa T,Takahashi M,Fukuda S,Ogose N

更新日期：1993-05-01 00:00:00

abstract：:The complication of metastasis from the primary tumor site to the distant organ is difficult to control. Tumor cells usually spread through the vascular system: lymphatics and/or blood; or by direct extension into adjacent sites. Transplantable prostate adenocarcinoma (PA-III) cells in L-W rats produces a tumor in the...

journal_title：Anticancer research

authors： Pollard M,Luckert PH

更新日期：1993-05-01 00:00:00

abstract：:We studied a combined utilization of serum tumour markers and proton nuclear magnetic resonance 1H NMR spectroscopy of plasma in the detection of pancreatic cancer. Serum concentrations of carcinoembryonic antigen (CEA), carboanhydrate antigens CA 50 and CA 242, and 1H NMR spectra of plasma were determined in a series...

journal_title：Anticancer research

authors： Pasanen PA,Kauppinen R,Eskelinen M,Partanen K,Pikkarainen P,Alhava E

更新日期：1993-05-01 00:00:00

abstract：:Two monoclonal antibodies, KM227 (IgM) and KM432 (IgG1), were established by immunizing mice with the crude membrane fraction of lung squamous cell carcinoma and the high-molecular-weight antigen in pleural perfusion from patients with lung adenocarcinoma, respectively. They were found to recognize the carbohydrate ep...

journal_title：Anticancer research

authors： Shitara K,Hanai N,Yoshida H

更新日期：1993-05-01 00:00:00

abstract：:A relationship was established between estradiol 16 alpha-hydroxylation, papillomavirus and its malignant sequelae. In this study, we determined that 16 alpha-hydroxylation was substantial in normal larynx and further increased in laryngeal papillomas. Estradiol or 16 alpha-hydroxyestrone stimulated proliferation in b...

journal_title：Anticancer research

authors： Newfield L,Goldsmith A,Bradlow HL,Auborn K

更新日期：1993-03-01 00:00:00

abstract：:We report here the first orthotopic transplant model for human ovarian cancer. Histologically-intact patient specimens of ovarian cancer were transplanted by microsurgical techniques under the capsule of the nude mouse ovary. The human tumors grew locally and gave rise to a patient-like metastatic pattern including th...

journal_title：Anticancer research

authors： Fu X,Hoffman RM

更新日期：1993-03-01 00:00:00

abstract：:25 consecutive leukemia patients (21 AML, 4 ALL) with either primary resistance (n = 22) or resistant relapse (n = 3) of all FAB-subtypes were treated with 1 or 2 cycles of ID-ara C (1 g/m2 i.v. q 12h days 1-6) and AMSA (120 mg/m2 i.v. days 5-7). Patients reaching CR received 1 cycle of intensive consolidation using a...

journal_title：Anticancer research

authors： Jehn U,Heinemann V

更新日期：1993-03-01 00:00:00

abstract：:Some non-differentiation-induction benzo[a]phenothiazines and mutagenic benz[c]acridines more potently inhibited the mitogen-induced blast transformation of human-peripheral blood lymphocytes than differentiation-induction and non-mutagenic counterparts and phenothiazines. Differential absorption spectrophotometry rev...

journal_title：Anticancer research

authors： Molnar J,Mandi Y,Petri I,Petofi S,Sakagami H,Kurihara T,Motohashi N

更新日期：1993-03-01 00:00:00

abstract：:A pharmacologically relevant modelling was attempted for screening of new molecules potentially active against non-small-cell lung cancers (NSCLCs). It was in this way that we investigated the in vivo chemosensitivity firstly of three human NSCLCs grafted onto nude mice, secondly of their in vitro primocultures, and t...

journal_title：Anticancer research

authors： Kruczynski A,Kiss R

更新日期：1993-03-01 00:00:00

abstract：:Tissue polypeptide specific antigen (TPS) is a new tumor proliferation serotest marker. The respective radioimmunodetective procedure is based on the application of monoclonal antibodies raised against one the principle epitopes of tissue polypeptide antigen (TPA). TPS is useful tool for the identification of prolifer...

journal_title：Anticancer research

authors： Tarle M,Kovacić K,Kastelan M

更新日期：1993-01-01 00:00:00

abstract：:The effects of a bacterial vaccine, heat-killed Clostridium butyricum MII 588 cells, on the metastasis of B16-F10 melanoma in BDF1 mice was investigated. The vaccine stimulated natural killer (NK) cell cytotoxic activity against YAC-1 target cells, which peaked at 72 hr after the pretreatment, whereas maximum macropha...

journal_title：Anticancer research

authors： Chen HY,Wu SL,Yeh MY,Chen CF,Mikami Y,Wu JS

更新日期：1993-01-01 00:00:00

abstract：:The limited restriction of eucaryotic chromosomes would facilitate our understanding of the aberrant genomes of genetic diseases and cancer. We have described methods for methylating eucaryotic chromosomes embedded in agarose plugs. We now describe how Cla I methylase can be utilized in a methylation-dependent restric...

journal_title：Anticancer research

authors： Wilson WW,Mebane EW,Hoffman RM

更新日期：1993-01-01 00:00:00

abstract：:As with SV40-transformed BHK cells (1), pretreatment of BHK cells with 1-beta-D-arabinofuranosylcytosine (araC) very markedly enhanced the resistance frequency to N-phosphonoacetyl-L-aspartate (PALA) but only modestly increased the resistance frequency to vincristine (VCR). AraC pretreatment of cells that already had ...

journal_title：Anticancer research

authors： Chen Y,Goz B,Kirkman L

更新日期：1993-01-01 00:00:00

abstract：:The in vitro chemosensitivity of MAC 15A ascites cells to CNC-alanylalanine and CNC-glycinemethylamide was assessed using a clonogenic assay system. In vitro stability studies and in vivo pharmacokinetics were performed using a reversed-phase HPLC technique. Initial concentrations of CNC-alanylalanine and CNC-glycinem...

journal_title：Anticancer research

authors： Matthew AM,Bibby MC,Eisenbrand G

更新日期：1993-01-01 00:00:00

abstract：:Four sorts of tumor proliferation-related markers were studied in 50 papillary carcinomas of the thyroid, and the results were correlated with the histologic subtypes of papillary thyroid carcinoma, which have been shown to be associated with the prognosis of the disease. The mitotic count analyzed by light microscopy...

journal_title：Anticancer research

authors： Mizukami Y,Nonomura A,Michigishi T,Noguchi M,Nakamura S,Hashimoto T

更新日期：1993-01-01 00:00:00

abstract：:We have examined several aspects of protein tyrosine kinase (PTK)-activity in the cytosolic and membrane fractions of both normal and malignant lymphoid cells. The expression of the PTK-encoding oncogenes fes, abl and src, was investigated with the use of antibodies generated to their respective gene products. These a...

journal_title：Anticancer research

authors： Punt CJ,Rijksen G,van Oirschot BA,Kester-Schipper GP,van der Heijden MC,Dekker AW,Staal GE

更新日期：1992-11-01 00:00:00

abstract：:We have investigated the combined effects of 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] and its fluoroanalog 26,26,26,27,27,27-hexafluoro-1,25-(OH)2D3 [F6-1,25-(OH)2D3] with sodium butyrate (NaB) on growth and differentiation of HL-60 human promyelocytic leukemia cells. F6-1,25-(OH)2D3 was 10-fold more active than 1,25-(...

journal_title：Anticancer research

authors： Yoshida M,Tanaka Y,Eguchi T,Ikekawa N,Saijo N

更新日期：1992-11-01 00:00:00

abstract：:The effects of an anti-CD3 mAb on induction of non-MHC restricted cytolysis was investigated. Peripheral blood mononuclear cells (PBMC) from normal donors (29) and cancer patients (18) were cultured in 100 U/ml of interleukin-2 (rIL-2) with and without anti-CD3 mAb (OKT3, 10 ng/ml) for the first 48 hours of incubation...

journal_title：Anticancer research

authors： Watanabe H,Narumi K,Stewart CC,Arbuck SG,Foon KA,Goldrosen MH

更新日期：1992-11-01 00:00:00

abstract：:The recombinant plasmid pBHIV-1 carrying the long terminal repeat (LTR) of the human immunodeficiency virus 1 (HIV-1), linked to the reported chloramphenicol acetyl transferase (CAT) gene, was introduced into human and rat fibroblasts. Stable transfectants were obtained which were resistant to genetecin and expressed ...

journal_title：Anticancer research

authors： Zoumpourlis V,Eliopoulos AG,Spandidos DA

更新日期：1992-11-01 00:00:00

abstract：:Consumption of dietary fat has been linked to the high incidence of certain cancers. However, recent research has stimulated interest in conjugated linoleic acid (CLA), a newly recognized anticarcinogenic fatty acid. Human MCF-7 breast cancer cells were incubated for 12 d in culture medium supplemented with various co...

journal_title：Anticancer research

authors： Shultz TD,Chew BP,Seaman WR

更新日期：1992-11-01 00:00:00

abstract：:Mutations in the p53 gene stimulate cell division. In our study we assessed the prognostic value of mutant p53 overexpression in cervical cancer stage FIGO III detected by immunohistochemistry. In 43 tissue specimens were detected p53 overexpression in 20 cases. Mean survival time was 36.4 (SE +/- 7.66) months in the ...

journal_title：Anticancer research

authors： Gitsch G,Kainz C,Joura E,Breitenecker G

更新日期：1992-11-01 00:00:00

abstract：:Overexpression of p53-protein appears to be a common event in primary breast cancer. It has been proposed that the presence of elevated levels of this protein may be an independent prognostic factor and may be important for the ability of a tumor to metastasize. This study was performed to evaluate the influence of im...

journal_title：Anticancer research

authors： Hanzal E,Gitsch G,Kohlberger P,Dadak C,Miechowiecka N,Breitenecker G

更新日期：1992-11-01 00:00:00

abstract：:Taking into account the possible regulatory influences of the beta-adrenergic system on lymphocyte proliferation as well as the proposed role of cyclic 3'-5'-adenosine monophosphate (cAMP) in the modulation of multidrug resistance (MDR) in tumour cells, we have tried to assess the status of the interactions between th...

journal_title：Anticancer research

authors： D'Amico C,Crescimanno M,Armata MG,Leonardi V,Palazzoadriano M,D'Alessandro N

更新日期：1992-11-01 00:00:00

abstract：:Allelic loss at specific chromosomal loci was demonstrated in carcinoma of the cervix (CaCx) obtained from Hong Kong Chinese by restriction fragment length polymorphism analysis. Altogether 12 patients with CaCx, 7 with cervical intraepithelial neoplasia (CIN) and 7 with normal cervical tissues were studied. Polymorph...

journal_title：Anticancer research

authors： Chung GT,Huang DP,Lo KW,Chan MK,Wong FW

更新日期：1992-09-01 00:00:00

abstract：:The cytotoxic effect of 5-FU (5-fluorouracil) was demonstrated to be enhanced by hyperthermia after treatment with 5-FU at even a comparatively low dose over fairly long periods. The cytotoxic effect of the combined treatment with 42 degrees C-hyperthermia and 1 microgram/ml 5-FU for 48 hrs, the cytotoxic effect of 42...

journal_title：Anticancer research

authors： Matsuoka H,Sugimachi K,Abe R,Ueo H,Akiyoshi T

更新日期：1992-09-01 00:00:00

abstract：:B-1 F is a cell line established from estrogen-responsive murine Leydig cell tumor and maintained in vitro. We investigated the effects of steroid hormones on the growth of tumors produced by the inoculation of B-1 F cells into mice. When tumor tissues were transplanted into castrated male mice, injections of estradio...

journal_title：Anticancer research

authors： Yamamoto T,Li I,Uchida N,Nishizawa Y,Yamamoto R,Terada N,Taniguchi H,Matsumoto K,Sato B

更新日期：1992-09-01 00:00:00

abstract：:In a previous study we demonstrated spontaneous fragility and hypersensitivity to fragile site induction by aphidicolin in lymphocytes from some neuroblastoma patients and their parents. Here we report data based on a total of 40 patients and 37 families. Possible correlations between higher sensitivity to aphidicolin...

journal_title：Anticancer research

authors： Vernole P,Tedeschi B,Melino G,Pianca C,Nicoletti B

更新日期：1992-09-01 00:00:00

abstract：:The effect of dehydroepiandrosterone (DHEA) (2 mg, twice daily p.o.) on the growth of the dimethylbenz (a) anthracene (DMBA)-induced mammary carcinoma was studied in intact and ovariectomized adult female rats. DHEA treatment stimulated the tumor growth in ovariectomized animals. Conversely, the tumors of intact rats ...

journal_title：Anticancer research

authors： Boccuzzi G,Aragno M,Brignardello E,Tamagno E,Conti G,Di Monaco M,Racca S,Danni O,Di Carlo F

更新日期：1992-09-01 00:00:00

abstract：:Experimental biochemical modulation of 1-hexylcarbamoyl-5-fluorouracil (HCFU) with l-leucovorin (LV) was carried out using human gastric (H-111) and colon (Co-4) carcinoma xenografts serially transplanted into nude mice. Thirty-five or 70 mg/kg HCFU dissolved in 0.2 ml of 1% hydroxymethyl cellulose was administered po...

journal_title：Anticancer research

authors： Kubota T,Kase S,Furukawa T,Tanino H,Kuo TH,Saikawa Y,Nishibori H,Ishibiki K,Kitajima M,Mabuchi K

更新日期：1992-09-01 00:00:00

abstract：:The number of silver stained nucleolar organiser regions (AgNORs) was assessed in biopsy specimens of 78 patients with prostatic adenocarcinoma followed up for a mean of 15.6 years. The number of Ag-NORs was related to histological features, clinical stage, DNA ploidy, S-phase fraction (SPF) and clinical outcome. In 3...

journal_title：Anticancer research

authors： Eskelinen M,Lipponen P,Syrjänen K

更新日期：1992-09-01 00:00:00

abstract：:In pancreatic neoplasias mutations in the first exon (codon 12) of K-ras gene occur at high frequency and seem to have a diagnostic significance. We set up the DGGE conditions to search for these mutations in pancreatic tumor sample DNAs. All samples were directly classified by simply comparing their DGGE patterns wit...

journal_title：Anticancer research

authors： Pellegata NS,Losekoot M,Fodde R,Pugliese V,Saccomanno S,Renault B,Bernini LF,Ranzani GN

更新日期：1992-09-01 00:00:00

abstract：:The present paper describes the generation and characterization of anti-idiotypic monoclonal antibodies (Ab2 MAbs) produced against the MOv19 MAb (Ab1 MAb), which shows a restricted reactivity with human ovarian carcinoma. The Ab2 MAbs were produced by immunizing mice with MOv19 conjugated to syngeneic mouse red blood...

journal_title：Anticancer research

authors： Pupa SM,Bazzini P,Menard S,Colnaghi MI

更新日期：1992-09-01 00:00:00

abstract：:We have previously found that in one of two human melanoma cell lines, potent increase in the polyamine catabolizing enzyme, spermidine/spermine N1-acetyltransferase (SSAT), correlate with growth sensitivity to the spermine analog, N1, N12-bis(ethyl) spermine (BESPM). Herein, we examine the generality of this SSAT res...

journal_title：Anticancer research

authors： Shappell NW,Miller JT,Bergeron RJ,Porter CW

更新日期：1992-07-01 00:00:00

abstract：:The abilities of 14 phenothiazines, 8 benzo[a]phenothiazines and 12 benz[c]acridines to induce an antibacterial effect against Escherichia coli K12 were compared. Several phenothiazines, which showed antiplasmid activity, displayed the most potent antibacterial activity. All benz[c]acridine derivatives were moderately...

journal_title：Anticancer research

authors： Motohashi N,Sakagami H,Kurihara T,Ferenczy L,Csuri K,Molnar J

更新日期：1992-07-01 00:00:00

abstract：:A copper complex with superoxide dismutase mimetic activity, Cu(II)2 (3,5-diisopropylsalicylate)4 (CuDIPS), was tested for activity against mammary cancer in female C3H/HeNCR mice. Initiation of treatment at 20 or at 30 weeks of age had a limited beneficial effect on survival rates. Further, a small, but not statistic...

journal_title：Anticancer research

authors： Crispens CG Jr,Sorenson JR

更新日期：1992-07-01 00:00:00